IDRIA S+
Cell-free conditioned and enriched autologous serum, prepared in a single visit. Glass-bead conditioning is designed to increase IL-1Ra and related anti-inflammatory cytokines, followed by a single centrifugation step for serum recovery.
PRODUCT OVERVIEW
IDRIA S+ is a glass-bead activation system that conditions autologous serum to increase anti-inflammatory cytokines—notably IL-1Ra—via monocyte stimulation on treated glass surfaces. Traditional ACS methods typically require hours of incubation at 37 °C, while IDRIA S+ is designed to avoid incubation and enable same-visit preparation. Result: 15 mL of cell-free, cytokine-enriched serum in 30–40 minutes overall.
IL-1Ra is a natural antagonist of IL-1 signaling and is widely studied in joint and tissue inflammation. ACS approaches using glass beads are known to increase IL-1Ra and related cytokines. Evidence and practice vary by indication.
IDRIA S+
The graph demonstrates the immunomodulatory effect of positively charged glass bead stimulation on monocytes.
A fold increase in IL-1Ra was observed compared to baseline levels, confirming strong anti-inflammatory activity.
IDRIA S+ is designed to enrich IL-1Ra in Cell-free conditioned serum. In an internal, independent test set (n=5), IL-1Ra increased versus baseline across all subjects (see figures). Published literature on glass-bead conditioning reports shifts in additional cytokines (e.g., IL-4, IL-10); Clinical relevance varies by indication and patient.
From a workflow perspective, preparation is practical: A room-temperature activation (30 minutes) followed by a 10-minute spin at 2,700 rcf (×g) enables same-visit serum recovery.
This combination of rapid preparation, anti-inflammatory cytokine upregulation, and regenerative growth factors highlights the positioned for clinician-directed use of this approach in advanced regenerative medicine and clinical practice.
WHAT IT IS
IDRIA S+ uses treated glass beads to condition autologous blood at room temperature. After a 30-minute activation and 10-minute spin at 2,700 rcf (×g), clinicians recover cell-free conditioned serum typically 15 mL from 30 mL blood (configuration-dependent).
WHY IDRIA S+
SAME-VISIT WORKFLOW
Conditioning at room temperature; No heated or overnight incubation
CYTOKINE ENRICHMENT
Designed to increase IL-1Ra; Literature reports shifts in other anti-inflammatory cytokines with bead-based conditioning
CELL-FREE OUTPUT
Low residual RBC/granulocyte carryover in serum
DEFINED PARAMETERS
Clear time/rcf/volume steps for reproducibility
HOW IT WORKS
DRAW
30 mL whole blood into the S+ tube (glass-bead matrix).
ACTIVATE
30 minutes at room temperature (per IFU).
CENTRIFUGE
10 minutes at 2,700 rcf (×g).
RECOVER CELL-FREE, CELL-FREE CONDITIONED SERUM
For clinician-directed use per local regulation.
TECHNICAL SNAPSHOT*
INPUT
30 mL whole blood
WORKFLOW TIME
30 min activation → 10 min spin @ 2700 rcf (xg)
TYPICAL OUTPUT
15 mL conditioned, cell-free serum
RESIDUAL CELLS
Low RBC/granulocyte carryover (serum profile)
What’s in
Cell-free conditioned serum is designed to increase IL-1Ra and may show shifts in other cytokines;
Composition depends on donor and protocol. Clinical relevance varies by indication and patient.
Design
Glass-bead conditioning for same-visit preparation;
Closed, single-use workflow for in-process integrity;
Unified standards — defined handling and documentation for consistent use.
Areas of
At clinician discretion, cytokine-conditioned autologous serum is used or studied across:
ORTHOPEDICS & SPORTS MEDICINE
DERMATOLOGY/ AESTHETICS
PLASTIC & RECONSTRUCTIVE
WOUND CARE
TENDINOPATHIES
Availability and permitted uses vary by country; Follow local regulations and professional guidance.
Quality &
- Parameters defined: time/rcf/volumes; Room-temperature activation
- Documentation: IFU/SOP, QC & batch templates, traceability
- Labeling: multilingual inserts/labels where applicable
IMPORTANT INFORMATION
Regulatory status: CE-marked where applicable. Availability, permitted uses, and labeling vary by country.
For professional use only. Product availability, regulatory status, and indications vary by market. Consult the IFU and local regulations before use.
Kit
IDRIA S+ (30 mL) glass-bead tube
Blood-draw accessories (by configuration)
Quick protocol card + IFU
