AutologIX by IDRIA Concept
Scientific Background
The IDRIA Concept brings structure and standardization to autologous regenerative therapies.
AutologIX by IDRIA Concept is a dual-technology system that isolates and concentrates exosomes and other plasma-derived regenerative molecules from the patient’s own blood — combining the precision of IDRIA G plasma preparation with the selectivity of ProtSmart 6 ultrafiltration.
In every human body, healing depends on communication between cells. This communication occurs through exosomes, nanosized vesicles (30–150 nm) that transport RNA, proteins, and signaling molecules between cells.
They act as the “language” of regeneration, coordinating how tissues respond to inflammation, injury, or aging.
Platelet-derived exosomes are particularly potent messengers. They activate fibroblasts, stimulate angiogenesis, regulate immune activity, and promote collagen synthesis. While traditional PRP relies on soluble growth factors, AutologIX focuses on the exosome fraction — where the true regenerative information resides.
By concentrating these exosomes within their natural plasma environment, AutologIX delivers a purely autologous, reproducible, and biologically active concentrate — optimized for safety, standardization, and clinical performance.
IDRIA Concept:
The IDRIA Concept is based on one principle: regeneration should be both biological and reproducible. To achieve that, the system unifies two steps into one continuous process:
PLASMA PREPARATION
With IDRIA G tubes
MOLECULAR CONCENTRATION
With ProtSmart 6 ultrafiltration
This combination reproduces the natural healing microenvironment — preserving exosomes, proteins, cytokines, and fibrin while eliminating unnecessary plasma volume and salts.
Exosomes and extracellular vesicles (EVs) are central to this concept: they are small enough to cross biological barriers, but powerful enough to modulate gene expression and cellular behavior. Their role extends beyond growth factor release — they orchestrate repair at the molecular level.
PREPARATION WORKFLOW
Step 1
PREPARE PLASMA WITH IDRIA G
Blood is collected into 2 IDRIA G tubes (2*23ml blood). Centrifugation separates the red cells from the plasma fractions (PRP + PPP), maintaining the integrity of platelets and exosomes.
Step 2
CONCENTRATE WITH PROTSMART 6
The combined plasma (approx. 24 mL) is transferred to ProtSmart 6 for ultrafiltration. The 15 kDa membrane allows water and salts to pass through while retaining exosomes, proteins, and cytokines. Within 8 minutes, the plasma is reduced to a target volume of 6-8ml.
Step 3
RECOVER THE EXOSOME-RICH CONCENTRATE
The final product is a cell-free, exosome-enriched plasma concentrate, standardized by defined time, speed, and volume parameters. It contains the patient’s own exosomes, cytokines, and plasma proteins in a physiologic balance that supports repair and regeneration.
Biological
The regenerative effects of autologIX arise from the combined actions of exosomes and their plasma co-factors:
EXOSOME COMMUNICATION
Exosomes deliver genetic and protein instructions that activate nearby cells. They stimulate fibroblasts and endothelial cells, encourage angiogenesis, and promote the synthesis of collagen and extracellular matrix. This restores cellular coordination and supports tissue organization.
GROWTH FACTOR AND CYTOKINE SYNERGY
The concentrate retains platelet-derived growth factors — PDGF, VEGF, TGF-β, IGF-1 — and cytokines such as IL-10 and TGF-β. These molecules amplify the biological effect of exosomes, guiding repair and improving microcirculation at the treatment site.
ANTI-INFLAMMATORY MODULATION
Exosomes regulate immune signaling by reducing pro-inflammatory cytokines (IL-1β, TNF-α) and promoting reparative macrophages (M2 type). This reduces inflammation, swelling, and discomfort, allowing regeneration to occur faster and more efficiently
TISSUE REMODELING
Fibrin fragments and plasma proteins form a temporary biological scaffold that supports cell migration and collagen alignment, ensuring that healing results in functional tissue rather than fibrosis.
Clinical
At clinician discretion and subject to local regulations, AutologIX is applied in:
MUSCULOSKELETAL MEDICINE
Tendinopathy, ligament injuries, muscle tears, osteoarthritis, post-traumatic pain
DERMATOLOGY & AESTHETIC MEDICINE
Skin rejuvenation, scars, acne, psoriasis, eczema
WOUND HEALING
Chronic ulcers, diabetic wounds, post-surgical recovery
HAIR RESTORATION
Androgenetic alopecia and diffuse hair loss
SEXUAL MEDICINE
Erectile dysfunction and male regenerative applications
ProtSmart 6
SCIENTIFIC VALIDATION
30T/mL Exosomes
Secures approximately 30 trillion exosomes per mL from autologous blood
Nanoparticle tracking analysis (NTA)
[Reference] 1. StemExoOne Co., Ltd., Independent Validation Report, 2024
Uniform Exosome Size
Confirmed uniform size and structural consistency
Distribution of Particles
Transmission Electron Microscopy
Growth Factor
Generates up to 4.8 times more effective growth factors compared to conventional PRP
Multiplex Growth Factor Quantification (5-Plex)
- PRP
- ProtSmart 6
(Unit: pg/mL)
[Reference] 1. Wongbee MedTech Report (2025-027-L.5Plex).
ProtSmart 6 CD Marker
Confirmed expression of effective exosome markers (CD9, CD63, CD81): proven high positive rates
Flow Cytometry
[Reference] 1. StemExoOne Co., Ltd., Independent Validation Report, 2024
Key
100% AUTOLOGOUS
Derived solely from the patient’s blood — no additives or foreign materials.
DEFINED PARAMETERS
Every step — spin speed, ultrafiltration time, and volume — is standardized.
CELL-FREE OUTPUT
Contains exosomes, proteins, and cytokines in a clear plasma solution.
SINGLE-VISIT WORKFLOW
Prepared in less than 15 minutes.
MODULAR DESIGN
IDRIA G and ProtSmart 6 function together as one complete system.
CE-MARKED COMPONENTS
Developed under European medical device regulations.
REPRODUCIBLE RESULTS
Controlled processes ensure consistent performance across treatments.
TECHNICAL OVERVIEW
IDRIA Concept:
AutologIX by IDRIA Concept is a standardized exosome-based system that combines precision, simplicity, and biological authenticity. By uniting IDRIA G plasma preparation with ProtSmart 6 ultrafiltration, it transforms a patient’s own plasma into a powerful autologous concentrate — rich in exosomes and regenerative plasma components.
This technology allows clinicians to apply the body’s natural healing mediators with accuracy, reproducibility, and confidence — ensuring every treatment reflects both science and biology working in harmony.
