Idria S+

Autologous Cytokines Conditioned Serum includes the IDRIA S+ 30ml tube and accessories for blood draw. IDRIA S+ comprises glass beads coated with positively charged ions. They interact with monocytes to stimulate the release of inflammatory mediators, including the anti-inflammatory IL-1Ra. Processing 30 ml of whole blood with IDRIA S+ yields 15 ml of autologous serum rich in cytokines.

IDRIA S+ Autologous Cytokines Conditioned Serum provides a hyper-concentration and cellular stimulation of IL-1Ra directly from the patient’s own blood,. Eliminating the need for any incubation process.

The presence of glass beads in IDRIA S+ activates monocytes to produce anti-inflammatory cytokines such as IL-1Ra. Also enhances the concentration of anti-inflammatory cytokines IL-4 and IL-10.

IL-1Ra, known as interleukin-1 receptor antagonist, is a naturally occurring cytokine that inhibits inflammation by binding to the IL-1 receptor, thereby preventing its activation. IL-1Ra not only blocks IL-1 but also exhibits analgesic and neuroprotective properties. It helps maintain proteinase balance and, in synergy with IL-4 and IL-10, promotes homeostasis in the microenvironment and tissue (including cartilage) synthesis.

Following centrifugation, a serum enriched with these cytokines and a significant amount of growth factors released from platelets (TGF-β, HGF, VEGF, IGF, PDGF) can be obtained. This cell-free serum exhibits high production of IL-1Ra within just 30 minutes, without the need for incubation.

Physicians can process 30 ml of blood and wait just 30 minutes for activation. Then to obtain 15 ml of Autologous Cytokines Conditioned Serum with high concentrations of anti-inflammatory cytokines in a single 10-minute spin (2700 rgf).