Concentrated Autologous Conditioned Serum iCCS

Discover the power of iCCS that stimulates the release of anti-inflammatory cytokines, providing pain relief, cartilage protection, and anti-aging benefits

IDRIA S+ contains glass beads coated with positively charged ions. The interaction between beads and monocytes can stimulate the cells to release inflammatory mediators, such as the anti-inflammatory IL-1Ra. As well as increase the concentration of anti-inflammatory cytokines IL-4 and IL-10 without requiring an incubation period. Within 40 minutes, IDRIA S+ can process 30 ml of whole blood to produce 15 ml of autologous serum rich in cytokines. IDRIA S+ is combined with the ultrafiltrator Protsmart.

By using the combination of IDRIA S+ and Protsmart 2 for a single treatment, it is possible to obtain a hyper-concentrated autologous serum rich in cytokines (Concentrated Autologous Conditioned Serum). The plasmatic water is eliminated, and the cytokines released from cells are concentrated.

Within the interleukin family, IL-1 is a pro-inflammatory cytokine released by immune cells during the early phases of inflammation. Its action can be regulated by IL-1Ra (interleukin-1 receptor antagonist), a naturally occurring cytokine released by monocytes. IL-1Ra binds to the IL-1 receptor, inhibiting the interaction between the receptor and the agonist, thereby preventing IL-1 intracellular signalling. IL-1Ra blocks the pro-inflammatory stimulus and promotes tissue regeneration.

Concentrated Autologous Conditioned Serum

The combination of these two technologies allows the production of an enriched conditioned serum (Concentrated Autologous Conditioned Serum) without the need for incubation. Resulting in a substantial quantity of anti-inflammatory cytokines suitable for a single treatment.

Injectable Concentrated Conditioned Serum (iCCS) is cell-free and abundant in anti-inflammatory cytokines and growth factors. This treatment provides anti-inflammatory, pain-relieving, cartilage-protecting effects, as well as anti-aging benefits.

Physicians can process 30 ml of blood and wait just 30 minutes for activation. Then obtain 15 ml of Injectable Concentrated Conditioned Serum with high concentrations of anti-inflammatory cytokines in a single 10-minute spin (2700 rgf). Afterwards, physicians can further process all serum components with ProtSmart 2 to achieve 5 ml of hyper-concentrated conditioned serum, enriched with proteins, growth factors, IL-1Ra, IL-4, and IL-10.

This process takes only a few minutes to be ready for direct injection into patients.

Hyper concentration of anabolic factors and plasma protein

Block of IL1 and catabolic elements

Single treatment

Indications

Osteoarthritis

These therapies are commonly used to treat osteoarthritis, a degenerative joint disease characterized by cartilage breakdown, inflammation, and pain. By reducing inflammation and modulating the immune response, these treatments can help alleviate pain and potentially slow down the degenerative process.

Post-surgical joint recovery

These therapies could be used to improve joint recovery following surgical procedures, such as arthroscopy. Or joint replacement, by reducing inflammation and promoting tissue repair.

Dermatology

The anti-inflammatory properties of these therapies might be helpful in managing inflammatory skin conditions such as psoriasis or atopic dermatitis.

Rheumatoid arthritis

Rheumatoid arthritis is an autoimmune condition causing joint inflammation, pain, and potential joint deformity. While these therapies have been less commonly used for rheumatoid arthritis, they may help manage symptoms by reducing inflammation and pain.

Hair loss

While more commonly treated with platelet-rich plasma (PRP) therapy, it is possible that these therapies could be investigated for their potential role in promoting hair follicle health and regrowth.

Gynecology

These therapies could potentially be explored for their effects on inflammatory gynecological conditions such as endometriosis or pelvic inflammatory disease, where reducing inflammation may help alleviate symptoms.

Tendinopathies

Inflammatory conditions of the tendons, such as tendonitis or tendinosis, may benefit from these therapies. They could potentially reduce inflammation and promote tissue healing.

Sports-related injuries

These treatments may be used for joint, ligament, or muscle injuries sustained during sports activities. With the aim of promoting healing, reducing inflammation, and shortening recovery times.

Urology

Their anti-inflammatory properties might be beneficial in the context of chronic prostatitis, interstitial cystitis, or other inflammatory urological conditions.

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iCCS